It is becoming increasingly clear that cells in the tumour microenvironemt play an important role in tumour growth and the formation of metastases. A RRCancer inter-axis collaboration demonstrated that carcinoma-associated fibroblasts should be considered as stable genomic compounds that exist within the complex microenvironment of the tumour. Their study suggests that the effects of these fibroblasts are unlikely to be due to genomic abnormalities in the fibroblasts themselves.
Hosein AN, Wu M, Arcand SL, Lavallée S, Hébert J, Tonin P and Basik M. 2010 Breast carcinoma associated fibroblasts rarely contain TP53 mutations and chromosomal aberrations. Cancer research 70(14):5770-7